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Medical Information:

This medicine contains the active ingredient prednisolone, which is a type of medicine known as a corticosteroid. Corticosteroids are hormones produced naturally by the adrenal glands which have many important functions, including control of inflammatory responses.

Prednisolone is a synthetic corticosteroid that is used to decrease inflammation in various different diseases and conditions. Corticosteroids are often simply called steroids, but it should be noted that they are very different from another group of steroids, called anabolic steroids, which have gained notoriety because of their abuse by some athletes and body builders.

Prednisolone works by acting within cells to prevent the release of certain chemicals that are important in the immune system. These chemicals are normally involved in producing immune and allergic responses, resulting in inflammation. By decreasing the release of these chemicals in a particular area, inflammation is reduced. This can help control a wide number of disease states, characterised by excessive inflammation. They include severe allergic reactions, inflammation of the lungs in asthma and inflammation of the joints in arthritis.

In high doses, prednisolone also decreases the numbers of white blood cells circulating in the blood. This, along with the decrease in inflammatory chemicals, can prevent the rejection of organ transplants, as it prevents the body from attacking foreign tissue. It is useful for the treatment of certain types of leukaemia, where there is an abnormally large production of certain white blood cells. It is also used to treat some diseases which are caused by the immune system attacking itself (auto immune diseases).

Prednisolone can also be given to people whose adrenal glands are not producing enough natural corticosteroids (adrenal insufficiency).

Prednisolone can be given orally or as an injection for all these purposes. It is also given by injection directly into a joint to relieve inflammation and pain and increase mobility of the affected joint, in conditions such as arthritis and tennis elbow.

Prednisolone is used in much higher doses than the levels of corticosteroids produced naturally by the body, and as such, the usual actions of corticosteroids become exaggerated and may be observed as side effects of this medicine.

What is it used for?

A form of cancer of the bone marrow (myeloma)Acute and lymphatic leukaemia Cancer of the lymph nodes (lymphoma) Diseases caused by the body's immune system attacking itself (autoimmune diseases such rheumatoid arthritis)Inflammatory disorders e.g. asthma, arthritis, severe allergic reactions, Crohn's disease, systemic lupus erythematosusInsufficient production of natural steroid hormones by the adrenal glands (adrenal insufficiency)Suppression of the immune system in organ transplantation